منابع مشابه
Melatonin, Neurogenesis, and Aging Brain
Aging is an irreversible process affecting all living organisms. During aging, all organs and tissues of the body reduce their functional capabilities, leading to a progressive loss of physical and cognitive performances. The loss of cells with age is directly related to apoptosis, a mechanism of cell death linked to mitochondrial failure. Attempting to understand the aging process, several the...
متن کاملNeurogenesis in the aging brain
Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central ...
متن کاملNeurogenesis in Diseases of Aging
Acute and chronic neurodegenerative diseases are common, disabling, and poorly responsive to current treatment. Stroke, the most frequent cause of acute neurodegeneration, has a prevalence of ~4.8 million and an incidence of ~700,000 individuals per year in the United States, where it is the third leading cause of death {1}. Even among those who survive stroke, disability due to hemiparesis, ga...
متن کاملWhen neurogenesis encounters aging and disease.
In this review, we consider the evidence that a reduction in neurogenesis underlies aging-related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD). The molecular and cellular alterations associated with impaired neurogenesis in the aging brain are discussed. Dysfunction of presenilin-1, misprocessing of amyloid precursor protein and toxic effects of hyperphosphor...
متن کاملAging of hippocampal neurogenesis and soy isoflavone
Throughout life, production of new neurons (granule cells) continues in the hippocampus of mammals including humans. Adult-generated granule cells play an important role in regulation of hippocampus-dependent cognitive functions and emotional behavior [1]. Each process of adult hippocampal neurogenesis is controlled by a variety of extrinsic and intrinsic factors. For instance, physical restrai...
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ژورنال
عنوان ژورنال: Reviews in the Neurosciences
سال: 2019
ISSN: 2191-0200,0334-1763
DOI: 10.1515/revneuro-2018-0084